South Carolina
All-time Wins by School
At least 500 wins
| All-Time | School | Record ('21) | Win% |
| 1 | Summerville | 835-243-25 (4-5-0) | 76.836 |
| 2 | Gaffney | 803-351-32 (15-0-0) | 69.056 |
| 3 | Lake View | 772-266-16 (9-3-0) | 74.004 |
| 4 | Sumter | 715-369-24 (10-2-0) | 65.614 |
| 5 | Greenwood | 700-280-34 (10-2-0) | 70.710 |
| 6 | Spartanburg | 692-396-36 (9-4-0) | 63.167 |
| 7 | Clinton | 675-368-25 (11-2-0) | 64.373 |
| 8 | Camden | 672-411-23 (11-3-0) | 61.799 |
| 9 | BATESBURG-LEESVILLE | 657-373-34 (3-4-0) | 63.346 |
| 10 | Greer | 656-376-26 (5-6-0) | 63.233 |
| 11 | Woodruff | 602-293-19 (5-6-0) | 66.904 |
| 12 | Berkeley | 598-308-14 (2-6-0) | 65.761 |
| 13 | Abbeville | 539-208-4 (12-1-0) | 72.037 |
Coaches, all-time & active, by Wins
At least 300 wins
| All-Time | Active | Coach | Record ('21) | Win% | Years | Seasons | Wins Per Season | School/Area |
| 1 | John McKissick | 620-156-13 | 79.404 | 1952-2014 | 63 | 9.841 | Summerville - | |
| 2 | Willie Varner | 383-132-10 | 73.905 | 1954-96 | 43 | 8.907 | Woodruff - | |
| 3 | Pinky Babb | 346-86-24 | 78.509 | 1935-81 | 47 | 7.362 | Greenwood SC - | |
| 4 | Jeff Herron | 312-54-0 | 85.246 | 1989-2018 | 31 | 10.065 | CamdenCo, OconeeCo, Wheeler, Cedar Shoals, Walton, PAC, Grayson, TL Hanna - |
